The Rabbit Anti-C13orf31/LACC1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to LACC1. This antibody recognizes Human antigen. The Rabbit Anti-C13orf31/LACC1 Antibody has been validated for the following applications: Immunoprecipitation.
Description
Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy and, more recently, ulcerative colitis and juvenile idiopathic arthritis. LACC1 function appears to promote fatty-acid oxidation, with concomitant inflammasome activation, reactive oxygen species production, and anti-bacterial responses in macrophages.LACC1 is expressed in both the cytoplasm and mitochondria. Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalling complex, and is critical for optimal NOD2-induced signalling, mitochondrial ROS (mtROS) production, cytokine secretion and bacterial clearance